Axon terminal clustering in nigrostriatal double grafts

Embryonic dopaminergic terminals of the ventral mesencephalon were cotransplanted with other immature neural tissues to the brain of newborn rats. Immunocytochemical localization of tyrosine hydroxylase in mature cografts with light and electron microscopy, demonstrated the existence of different axon terminal distributions in different grafts. These findings implicate the influence of local cell interactions in determining axon arborization.