Discovery of PANoptosis-related signatures correlates with immune cell infiltration in psoriasis
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View abstract on PubMed
Summary
This summary is machine-generated.This study identifies five PANoptosis-related signatures (PANoptosis-sig) as potential biomarkers for psoriasis, revealing two distinct molecular subtypes and novel therapeutic targets for this inflammatory skin disease.
Area Of Science
- Immunodermatology
- Cellular Biology
- Molecular Medicine
Background
- Psoriasis is a chronic inflammatory skin condition characterized by frequent relapses.
- Dysregulation of keratinocyte apoptosis is a key factor in psoriasis pathogenesis.
- PANoptosis, a cell death process involving pyroptosis, apoptosis, and necroptosis, is implicated but its role in psoriasis remains unclear.
Purpose Of The Study
- To identify PANoptosis-related molecular signatures in psoriasis.
- To develop predictive and diagnostic models for psoriasis using these signatures.
- To explore psoriasis molecular subtypes based on PANoptosis signatures.
Main Methods
- Transcriptional and protein level analysis of skin tissues from psoriasis patients and healthy controls.
- Identification of five PANoptosis-related signatures (TYMP, S100A8, S100A9, NAMPT, LCN2).
- Enrichment analysis, single-cell transcriptome analysis, predictive model construction, and unsupervised consensus clustering.
Main Results
- Five key PANoptosis-sig were identified, enriched in inflammatory pathways like IL-17 signaling.
- TYMP and NAMPT showed broad cell expression, while LCN2, S100A8, and S100A9 were highly expressed in keratinocytes.
- Two distinct psoriasis molecular subtypes were identified, differing in immune cell infiltration and sensitivity to immune checkpoints.
Conclusions
- The identified PANoptosis-sig serve as potential biomarkers for psoriasis diagnosis and prognosis.
- These signatures offer novel therapeutic targets for psoriasis treatment.
- The study enhances understanding of PANoptosis mechanisms in psoriasis development and heterogeneity.
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