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Multi-level structured nanoparticles prepared by microfluidics control method for efficient and sensitive

Tong Jiang1, Li Dai1, Yanan Lou1

  • 1Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, Shandong, China.

Journal of Colloid and Interface Science
|October 31, 2024
PubMed
Summary

Researchers developed novel chemiluminescence (CL) nanoparticles using microfluidic technology for enhanced nanomaterial synthesis. These HPL nanoparticles enable sensitive detection of tumor markers like carcinoembryonic antigen (CEA).

Keywords:
Carcinoembryonic antigenChemiluminescent immunosensorHematinLuminolMicrofluidics

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Area of Science:

  • Nanoscience and Nanotechnology
  • Biomedical Engineering
  • Materials Science

Background:

  • Nanomaterial properties are critically dependent on size effects, posing challenges in controlling morphology during self-assembly.
  • Microfluidic technology provides precise control over micro-level fluid dynamics, essential for manipulating nanomaterial synthesis.
  • Developing efficient chemiluminescence (CL) systems requires innovative approaches to enhance catalytic capabilities and structural control.

Purpose of the Study:

  • To synthesize novel amphiphilic molecules (HP) and encapsulate luminol within them using microfluidics to create highly efficient CL nanoparticles (HPL).
  • To investigate the size effects and multi-level structures of HPL nanoparticles and their impact on catalytic CL.
  • To develop a CL immunosensor utilizing HPL nanoparticles for sensitive detection of the tumor marker carcinoembryonic antigen (CEA).

Main Methods:

  • Synthesis of amphiphilic HP molecules (Hematin@NH2-PEG-COOH) via hematin modification.
  • Encapsulation of luminol within HP molecules using advanced microfluidic techniques to form HPL nanoparticles.
  • Characterization of HPL nanoparticle properties, including size effects and catalytic CL activity.
  • Development and validation of a CL immunosensor for CEA detection using HPL nanoparticles as luminescent markers.

Main Results:

  • Successfully synthesized highly efficient chemiluminescence (CL) HPL (HP@Luminol) nanoparticles with controlled size and multi-level structures.
  • Demonstrated enhanced catalytic capabilities for CL due to the unique structural attributes of the HPL nanoparticles.
  • Developed a CL immunosensor for sensitive detection of carcinoembryonic antigen (CEA), achieving satisfactory results.

Conclusions:

  • Microfluidic technology enables precise control over nanomaterial synthesis, leading to innovative HPL nanoparticles with enhanced CL properties.
  • The developed HPL nanoparticles offer a promising platform for sensitive biomarker detection, expanding applications in nanoscience and biosensing.
  • This study presents a novel strategy for designing advanced nanomaterials and highlights the potential of microfluidics in developing sensitive diagnostic tools.