Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Zygotic Development And Stem Cell Formation

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...

Cleavage and Blastulation

Cleavage and Blastulation

After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The mammalian preimplantation embryo: Its role in the environmental programming of postnatal health and performance.

Animal reproduction science·2023

Same author

Preimplantation or gestation/lactation high-fat diet alters adult offspring metabolism and neurogenesis.

Brain communications·2023

Same author

Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells.

Stem cell reviews and reports·2022

Same author

Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk.

International journal of environmental research and public health·2021

Same author

Blastocyst trophectoderm endocytic activation, a marker of adverse developmental programming.

Reproduction (Cambridge, England)·2021

Same author

Advanced maternal age perturbs mouse embryo development and alters the phenotype of derived embryonic stem cells.

Journal of developmental origins of health and disease·2021

Search research articles

Related Experiment Video

Updated: Jun 9, 2025

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Preimplantation trophectoderm: A 'quick-fix' protector for embryo survival?

Tom P Fleming¹

¹School of Biological Sciences, Southampton General Hospital, University of Southampton, Southampton, SO16 6YD, UK.

Developmental Biology

|October 31, 2024

Summary

The trophectoderm (TE) epithelium protects the early mammalian embryo. Its differentiation is crucial for blastocyst development, involving cell polarization and signaling, with implications for embryo survival and clinical relevance.

Keywords:

Blastocyst Cytoplasmic processes Differentiation Endocytosis Epithelium Filopodia Trophectoderm mTORC1

More Related Videos

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

Related Experiment Videos

Last Updated: Jun 9, 2025

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Protocol for Human Blastoids Modeling Blastocyst Development and Implantation

Published on: August 10, 2022

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Derivation of Mouse Trophoblast Stem Cells from Blastocysts

Published on: June 8, 2010

Area of Science:

Developmental Biology
Cell Biology
Embryology

Background:

The trophectoderm (TE) is the mammalian blastocyst's outer layer, essential for blastocoel formation via vectorial transport.
TE differentiation is integrated with blastocyst morphogenesis, involving cell polarization, asymmetric cell division, signaling, transcription factors, and inheritance.

Purpose of the Study:

To assess the protective function of TE differentiation for early embryo survival.
To examine specific examples of TE differentiation, including filopodia formation and endocytic system maturation.

Main Methods:

Observational studies on mouse embryos.
Analysis of cellular processes within the TE.

Main Results:

TE differentiation provides physical and cellular protection to developing embryo lineages.
TE exhibits specialized cellular processes, such as filopodia formation and polarized endocytosis, contributing to embryo protection.

Conclusions:

TE plays a broad role in regulating early embryo morphogenesis and environmental protection.
Understanding TE differentiation has significant biological and clinical relevance for embryo development and reproductive health.