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Updated: Jun 9, 2025

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
Published on: July 21, 2023
Physiological Pacing for the Prevention and Treatment of Heart Failure: a State-of-the-Art Review
Margaret Infeld1, Jamie A Cyr2, Damián Sánchez-Quintana3
1CardioVascular Center, Tufts Medical Center and Tufts University School of Medicine, Boston, MA, USA.
Abstract:
Permanent pacing from the right ventricular apex can reduce quality of life and increase the risk of heart failure and death. This review summarizes the milestones in the evolution of pacemakers toward physiological pacing with biventricular pacing systems and lead implantation into the cardiac conduction system to synchronize cardiac contraction and relaxation. Both approaches aim to reproduce normal cardiac activation and help to prevent and treat heart failure. This review introduces the basic concepts and clinical evidence and discusses the practical uses of physiological pacing.
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