Regulatory network of non-coding RNA in Helicobacter pylori: A systematic approach

Helicobacter pylori, a pathogenic bacterium residing in the human gut microbiome, is a forefront pillar of biological factors known to cause gastric cancer (GC) in human. At genetic levels, the emerging field of RNAomics has shed light on the need to investigate a significant biological macromolecule known as Noncoding RNA that plays pivotal role in diverse biological and functional facets of bacterial pathogenesis and survival. Notably, H. pylori harbour an array of coding and non-coding RNAs (ncRNAs). These ncRNAs exert pleiotropic effects, targeting numerous cellular pathways and thereby orchestrating transcriptomic-level regulation to adapt to various environmental conditions. Regrettably, the existing literature on H. pylori lacks a comprehensive and concise overview about these RNAs. Acknowledging this significant gap, our study systematically explores the regulation of biomarker ncRNA classes, associated molecules, and their therapeutic targets within the different cellular realm of bacterium. This elucidation of functional domains by computational and in vitro approach will provide essential insights for developing modern, synthetic, and personalized strategies to target these ncRNAs, ultimately eradicating the pathogenesis. Therefore, this research holds significant promise for advancing our potential understanding of H. pylori pathogenesis and paving the way for innovative therapeutic interventions.