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07:03
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
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Hyperhomocysteinemia is linked to MASLD
Carlo De Matteis1, Lucilla Crudele1, Ersilia Di Buduo1
1Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
European Journal of Internal Medicine
|October 31, 2024
Summary
Elevated homocysteine (Hcy) levels are linked to metabolic-associated steatotic liver disease (MASLD). This study found hyperhomocysteinemia (HHcy) in MASLD patients, associated with poor glucose and lipid profiles and low Vitamin D.
Area of Science:
- Biochemistry
- Hepatology
- Cardiovascular Medicine
Background:
- Elevated homocysteine (Hcy) is observed in cardiovascular diseases (CVD), diabetes, and metabolic-associated steatotic liver disease (MASLD).
- Understanding the etiological role of Hcy in MASLD is crucial for patient management.
Purpose of the Study:
- To investigate the association between homocysteine (Hcy) levels and metabolic-associated steatotic liver disease (MASLD).
- To analyze the clinical and biochemical characteristics of outpatients with hyperhomocysteinemia (HHcy).
Main Methods:
- Retrospective analysis of 901 outpatients' physical and biochemical data.
- Abdominal and carotid ultrasound to assess liver steatosis, carotid intima-media thickness (IMT), and atherosclerotic plaque.
- Statistical analysis to determine the relationship between Hcy, MASLD, and other health indicators.
Main Results:
- Hyperhomocysteinemia (HHcy) was present in 16% of patients, associated with impaired glucose metabolism, altered lipid profiles, low Vitamin D, and increased cardiovascular risk.
- A significant association was found between Hcy and MASLD (OR=3.6), persisting after adjusting for confounders (OR=3.2).
- MASLD patients exhibited higher Hcy levels and correlations between Hcy, waist circumference, HDL-c, and Vitamin D.
Conclusions:
- Hyperhomocysteinemia (HHcy) is prevalent in MASLD patients and linked to lower Vitamin D and adverse glucose/lipid profiles.
- Monitoring Hcy levels may aid in managing patients at risk for MASLD and associated complications.
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