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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

289
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
289

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Decoding the human prenatal immune system with single-cell multi-omics.

Muzlifah Haniffa1,2,3,4, Aidan Maartens5, Elena Winheim5

  • 1Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK. mh32@sanger.ac.uk.

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Summary
This summary is machine-generated.

Understanding human immune system development is key. New genomic technologies are revealing the intricate timings, cell types, and environments critical for building this complex defense network from prenatal stages onward.

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Area of Science:

  • Immunology
  • Developmental Biology
  • Genomics

Background:

  • The human immune system comprises diverse cell types with specialized functions, forming intricate networks for pathogen defense.
  • The developmental processes underlying the complexity of the human immune system are not yet fully understood.
  • Direct study of human development has historically been challenging.

Purpose of the Study:

  • To review current understanding of human immune system development.
  • To highlight key factors including timings, cellular transitions, and tissue microenvironments.
  • To compare human immune development with model organisms and in vitro systems.

Main Methods:

  • Leveraging recent advances in single-cell and spatial genomics.
  • Utilizing data from initiatives like the Human Cell Atlas.
  • Synthesizing findings from multiple studies mapping immune system development.

Main Results:

  • New studies provide unprecedented detail on human immune system development.
  • Identification of crucial timings, cellular transitions, and microenvironmental influences.
  • Comparative analysis with model species and in vitro systems offers insights.

Conclusions:

  • Advances in genomics are revolutionizing our understanding of prenatal immune development.
  • Knowledge of early immune development is essential for understanding human diseases.
  • This review consolidates current findings and future directions in the field.