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Patients' knowledge about renal secondary effects of anti-tumoral drugs and renal protection measures
Pauline Corbaux1,2, Matthieu Bainaud3,4, Adrien Rousseau3,5
1Medical Oncology, Institut de Cancérologie Et d'Hématologie Universitaire de Saint-Étienne (ICHUSE), Centre Hospitalier Universitaire de Saint-Etienne, Service d'oncologie Médicale, Av. Albert Raimond, 42270, Saint-Priest-en-Jarez, France. pauline.corbaux@chu-st-etienne.fr.
Purpose:
Onco-nephrology is an emerging subspecialty aiming to better understand and prevent renal events in cancer patients. We assessed patients' knowledge about (1) oncological/hematological treatments induced renal toxicity and (2) kidney protective measures.
Methods:
Adult patients receiving systemic anti-tumor treatments in multiple day hospital units in France answered a self-administered questionnaire about their knowledge and expectations related to treatment-associated renal toxicity.
Results:
In total, 621 questionnaires were collected in 8 units from November 2021 to January 2022. Among respondents, 84.5% were treated for a solid tumor. Overall, 34.3% (n = 208) patients reported they had some knowledge about potential renal adverse events related to their anticancer treatment, and 38.5% (n = 234) about kidney protection measures. Their referring oncologist or hematologist represented the commonest source of knowledge (67.8%). Sufficient hydration was cited as a kidney protection measure by 93.2% (n = 218) of patients declaring some knowledge about renal toxicity; prevention of nausea/vomiting by 52.6% (n = 123). Consumption of still and alkaline water was chosen by respectively 64.4% (n = 400) and 16.8% (n = 104) of participants to correct dehydration. A majority of patients expressed strong interest for receiving more information about renal toxicity and prevention: median Likert scale score was 10/10 (Q1-Q3, 5-10), with online resources mentioned as the most desired source of information.
Conclusion:
One-third of patients declared they had some knowledge about potential renal toxicity of their oncologic treatment and the ways to prevent them, especially regarding hydration. However, a majority expressed interest for dedicated information, which conducted to the elaboration of free online educational sheets for patients.
Insights
Cancer patients have limited knowledge of kidney damage from treatments. Most desire more information on preventing renal toxicity, particularly regarding hydration. Educational resources are being developed to meet this need.
Area of Science:
- Oncology
- Nephrology
- Patient Education
Background:
- Onco-nephrology is an emerging field focused on renal complications in cancer patients.
- Cancer treatments can induce significant renal toxicity, impacting patient outcomes.
- Understanding patient knowledge is crucial for developing effective preventive strategies.
Purpose of the Study:
- To assess cancer patients' awareness of treatment-induced renal toxicity.
- To evaluate patients' knowledge of kidney protective measures during cancer therapy.
- To identify patient preferences for receiving information on renal health in oncology.
Main Methods:
- A self-administered questionnaire was used to collect data from adult patients undergoing systemic anti-tumor treatments in France.
- The study included 621 patients across 8 hospital units between November 2021 and January 2022.
- Data focused on patient knowledge, expectations, and information sources regarding treatment-associated renal toxicity.
Main Results:
- Only 34.3% of patients reported awareness of potential renal adverse events from their cancer treatment.
- 38.5% of patients knew about kidney protection measures, with hydration being the most recognized (93.2%).
- A significant majority (median Likert score 10/10) expressed strong interest in receiving more information, preferring online resources.
Conclusions:
- A significant knowledge gap exists among cancer patients regarding treatment-induced renal toxicity and prevention strategies.
- Hydration is the most understood protective measure, but comprehensive knowledge remains limited.
- Patient demand for accessible information has led to the creation of online educational materials.
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