Proinflammatory factors inhibition and fish oil treatment: A promising therapy for neonatal seizures
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View abstract on PubMed
Summary
This summary is machine-generated.Fish oil (FO) supplementation during lactation reduced seizures, brain damage, and inflammation in infant rats exposed to hypoxia. This neuroprotective effect improved cognitive and behavioral outcomes in the offspring.
Area Of Science
- Neuroscience
- Developmental Biology
- Pharmacology
Background
- Infant brain injury from hypoxia causes lifelong neurological deficits.
- Fish oil (FO) has shown potential neuroprotective properties in brain injury models.
- The impact of FO during lactation on hypoxia-induced brain injury requires further investigation.
Purpose Of The Study
- To evaluate the neuroprotective effects of fish oil (FO) administered during lactation in a rat model of infant hypoxia.
- To assess the impact of FO on seizure activity, behavioral performance, brain histomorphometry, and neuroinflammation.
Main Methods
- Male Wistar rats were divided into Sham, hypoxia, FO, and FO+hypoxia groups.
- Hypoxia was induced in neonates on postnatal day 12.
- Fish oil was administered orally to dams during the lactation period.
- Seizure activity, behavioral tests (NORT, rotarod, open field), hippocampal/cerebellar histomorphometry, and gene expression of TNF-α and IL-1β were analyzed.
Main Results
- Hypoxia significantly increased seizure activity, neuronal cell death, atrophy in the hippocampus and cerebellum, neuroinflammation (TNF-α, IL-1β expression), and behavioral deficits.
- Fish oil administration to hypoxic rats significantly reduced seizure frequency, neuroinflammation, and neuronal damage.
- Fish oil supplementation improved behavioral performance and cognitive functions in rats exposed to hypoxia.
Conclusions
- Dietary fish oil during lactation exerts significant neuroprotective effects against hypoxia-induced brain injury in developing rats.
- FO mitigates seizure susceptibility, neuroinflammation, and neuronal loss, while enhancing cognitive and behavioral outcomes.
- Fish oil represents a promising nutritional strategy for preventing or reducing the severity of infant hypoxic-brain injury.
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