Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Preserved Barrier Integrity and Altered Immune Profiles in Chronic Cannabis Users: Potential Roles of Δ9-Tetrahydrocannabinol.

bioRxiv : the preprint server for biology·2026

Same author

Safety and Efficacy of Nerinetide at Year 1 in Participants Enrolled in ESCAPE-NEXT: A Multicenter, Double-Blind, Randomized Controlled Trial.

Journal of the American Heart Association·2026

Same author

Association of Successful Recanalization and Functional Outcomes in Minor Ischemic Stroke With Proven Occlusion: A Secondary Analysis of TEMPO-2 Trial.

Stroke·2026

Same author

Predictors and Consequences of Serious Adverse Events in Patients Treated With Thrombolysis: A Prespecified Secondary Analysis of the AcT Trial.

Journal of the American Heart Association·2026

Same author

Correction to: Real-world outcomes of thrombectomy for distal medium vessel occlusions in the Middle East and North Africa region: a multicenter registry analysis.

Neuroradiology·2026

Same author

Tenecteplase versus alteplase in elderly stroke: a post hoc analysis of the AcT trial.

Stroke and vascular neurology·2026

Search research articles

Related Experiment Video

Updated: May 11, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Workflow and Short-Term Functional Outcomes in Simultaneous Acute Code Stroke Activation and Stroke Reperfusion

Robert Joseph Sarmiento¹, Amanda Wagner¹, Asif Sheriff²

¹Department of Medicine, University of Alberta, Edmonton, AB T6G2B7, Canada; rsarmien@ualberta.ca (R.J.S.).

|November 1, 2024

Summary

This summary is machine-generated.

Simultaneous acute code stroke activation (ACSA) is common in reperfusion therapy patients. While it prolonged door-to-CT times, it did not impact 90-day home time, suggesting workflow optimization is key.

Keywords:

acute code stroke activations acute reperfusion treatment acute stroke patient outcomes simultaneity triage

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Published on: November 22, 2024

Related Experiment Videos

Last Updated: May 11, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Optimization of the Longa Middle Cerebral Artery Occlusion Method for Complete Reperfusion

Published on: November 22, 2024

Area of Science:

Emergency Medicine
Neurology
Healthcare Management

Background:

Simultaneous acute code stroke activation (ACSA) presents a growing challenge in emergency departments.
The impact of simultaneous ACSA on patient workflow and outcomes is not well understood.
Optimizing emergency care for acute stroke patients requires evaluating complex activation scenarios.

Purpose of the Study:

To assess the effect of simultaneous ACSA on workflow metrics, specifically door-to-CT (DTC) time.
To evaluate the impact of simultaneous ACSA on functional outcome, measured as home time at 90 days.
To determine the frequency of simultaneous ACSA in patients receiving acute reperfusion therapies.

Main Methods:

Retrospective analysis of 2605 acute code stroke activations.
Defined simultaneous ACSA based on timing relative to reperfusion therapies (thrombolysis, thrombectomy) or no reperfusion.
Assessed workflow using door-to-CT (DTC) time and functional outcome using 90-day home time.

Main Results:

33% of ACSA events were simultaneous, with 40.4% of patients receiving reperfusion therapy undergoing simultaneous treatments.
Grade 3 simultaneous ACSA was associated with significantly prolonged median DTC times (18 vs. 15 minutes).
No significant difference in median 90-day home time was observed between simultaneous and non-simultaneous ACSA patients.

Conclusions:

Simultaneous ACSA is a frequent occurrence in patients undergoing acute reperfusion therapies.
While simultaneous ACSA can delay diagnostic imaging (DTC), it does not appear to negatively affect long-term functional outcomes (90-day home time).
Implementing optimal workflows in high-volume stroke centers may mitigate the clinical and system burdens associated with simultaneous ACSA.