Progress in modeling avian hyperuricemia and gout (Review)

Area of Science:

• Veterinary Medicine
• Biomedical Research
• Gout Pathogenesis

Background:

• Human organ tissues are susceptible to hyperuricemia (HUA), a condition that diminishes quality of life and can advance to gout.
• Poultry share similar uric acid metabolism pathways with humans, suggesting their potential as models for HUA and gout.

Purpose of the Study:

• To review the progress and methodologies of poultry-induced hyperuricemia (HUA) and gout models.
• To evaluate detection indices and current challenges associated with these poultry models.

Main Methods:

• Review of existing literature on chicken models for HUA and gout.
• Analysis of induction methods, focusing on combined water and food strategies.
• Assessment of detection indices and model stability.

Main Results:

• The combined water and food induction method demonstrates a higher success rate and stability in poultry models.
• Poultry models exhibit reduced kidney damage compared to murine models.
• These poultry models are characterized by their stability and long-lasting nature.

Conclusions:

• Poultry models provide a robust and stable platform for investigating hyperuricemia (HUA) and gout.
• The reduced kidney pathology in poultry models offers advantages over traditional mouse models.
• Further research utilizing these poultry models can advance understanding of HUA and gout pathogenesis and treatment.