Related Experiment Video
Updated: Jun 8, 2025

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
Published on: November 11, 2017
Intraclass Correlation in Paired Associative Stimulation and Metaplasticity
Giuditta Schapira1, Justin Chang1, Yeun Kim1
1Ahmanson-Lovelace Brain Mapping Center, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Abstract:
Paired associative stimulation (PAS) is a widely used noninvasive brain stimulation protocol to assess neural plasticity. Its reproducibility, however, has been rarely tested and with mixed results. With two consecutive studies, we aimed to provide further tests and a more systematic assessment of PAS reproducibility. We measured intraclass correlation coefficients (ICCs)-a widely used tool to assess whether groups of measurements resemble each other-in two PAS studies on healthy volunteers. The first study included five PAS sessions recording 10 MEPS every 10 min for an hour post-PAS. The second study included two PAS sessions recording 50 MEPS at 20 and 50 min post-PAS, based on analyses from the first study. In both studies PAS sessions were spaced one week apart. Within sessions ICC was fair to excellent for both studies, yet between sessions ICC was poor for both studies. We suggest that long term meta-plasticity effects (longer than one week) may interfere with between sessions reproducibility.
More Related Videos
08:43Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning
Published on: October 22, 2015
10:25Simultaneous Transcranial Alternating Current Stimulation and Functional Magnetic Resonance Imaging
Published on: June 5, 2017
Related Concept Videos
Real-World Application of Classical Conditioning
Higher-order, or second-order, conditioning occurs when a neutral stimulus becomes associated with an already established conditioned stimulus through repeated pairings. For instance, if a dog has been...
Associative Learning
Classical conditioning, also known...
Long-term Potentiation
Hebbian LTP
LTP can occur when...
Classical Conditioning
Ivan Pavlov observed that dogs...