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Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
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Understanding Pain in Polycystic Ovary Syndrome: Health Risks and Treatment Effectiveness
Tess Cherlin1, Stephanie Mohammed1, Sasha Ottey2
1Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA, United States.
Medrxiv : the Preprint Server for Health Sciences
|November 1, 2024
Summary
Polycystic ovary syndrome (PCOS) significantly impacts women, with nearly 20% experiencing pain. Addressing pain in PCOS management is crucial for improving patient health outcomes.
Area of Science:
- Endocrinology
- Reproductive Health
- Pain Management
Background:
- Polycystic ovary syndrome (PCOS) is a common endocrine disorder.
- Pain, including dysmenorrhea and pelvic pain, is an under-recognized symptom in PCOS.
- The impact of pain on PCOS patients requires further investigation.
Purpose of the Study:
- To determine the prevalence of pain in women diagnosed with PCOS.
- To analyze pain prevalence based on race and PCOS medication use.
- To assess the association between PCOS, pain, and future health outcomes.
Main Methods:
- Retrospective analysis of electronic health records (EHR) from the TriNetX Global Network.
- Involved over 76 million women across 120 healthcare organizations.
- Calculated relative risk ratios (RR) for health outcomes, stratified by race.
Main Results:
- 19.21% of women with PCOS reported pain.
- Highest pain prevalence observed in Black/African American (32.11%) and White (30.75%) women.
- PCOS and pain cohorts showed increased RR for conditions like infertility and obesity; PCOS medications correlated with reduced pain diagnoses.
Conclusions:
- Pain is a significant comorbidity in Polycystic Ovary Syndrome.
- Racial disparities exist in PCOS-related health outcomes.
- Integrating pain assessment and management into PCOS care is essential for better patient outcomes.
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