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Updated: Jun 8, 2025

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Effective management of multidrug-resistant HIV with lenacapavir and fostemsavir: A case study
Francisca Bartilotti Matos1, Dara Mbanze1, Perpétua Gomes2,3
1Serviço de Doenças Infeciosas, Unidade Local de Saúde Gaia/Espinho, Vila Nova de Gaia, Portugal.
Abstract:
Resistance to antiretroviral therapy is an increasing challenge in the management of HIV. We present the case of a woman living with HIV, with a history of multiple treatment regimens and resistances to antiretrovirals, who has been successfully treated with a combination of lenacapavir and fostemsavir for the past year, obtaining an undetectable viral load within one month of starting therapy and reporting no serious side effects. This case is amongst the first to document the combined use of lenacapivir and fostemsavir in treating multidrug-resistant HIV. It supports the potential of these novel agents in managing complex cases of HIV resistance.
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