Minimize flow-induced uncertainty in polarization sensitive optical coherence tomography imaging using eigen
Optics Letters
|November 1, 2024
Summary
Blood flow disrupts polarization measurements in optical coherence tomography. A new eigen decomposition method separates static and dynamic signals, enabling accurate polarization-sensitive optical coherence tomography (PSOCT) of underlying tissues, even with blood flow present.
Area of Science:
- Biomedical Optics
- Optical Coherence Tomography
- Photonics
Background:
- Blood flow introduces instability in polarization measurements during polarization-sensitive optical coherence tomography (PSOCT).
- This instability complicates the analysis of subsurface tissue properties.
- Accurate polarization measurements are crucial for various biomedical applications.
Purpose of the Study:
- To develop a method to overcome polarization instability caused by blood flow in PSOCT.
- To enable reliable polarization measurements of tissues beneath blood flow.
- To validate the proposed method using phantoms and in vivo imaging.
Main Methods:
- An eigen decomposition method was proposed to separate static and dynamic scattering signals.
- Flow phantoms using Intralipid solution and 3D-printed birefringent materials were utilized.
- In vivo imaging of the human nail fold was performed to demonstrate the method's utility.
Main Results:
- The eigen decomposition method successfully separated static and dynamic scattering signals.
- Flow-induced effects on optical axis, phase retardation, and degree of polarization uniformity were quantified.
- The method provided stable polarization measurements in the presence of simulated blood flow.
Conclusions:
- The proposed eigen decomposition method effectively addresses polarization instability in PSOCT caused by blood flow.
- This technique enhances the reliability of subsurface tissue polarization measurements.
- The method shows promise for in vivo applications, as demonstrated in human nail fold imaging.
More Related Videos
12:54Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
3.2K
14:18Automation of Mode Locking in a Nonlinear Polarization Rotation Fiber Laser through Output Polarization Measurements
Published on: February 28, 2016
11.3K
Related Concept Videos
01:29Potential Due to a Polarized Object
367
A neutral atom consists of a positively charged nucleus surrounded by a negatively charged electron cloud. When placed in an external electric field, the external electric force pulls the electrons and nucleus apart, opposite to the intrinsic attraction between the nucleus and the electrons. The opposing forces balance each other with a slight shift between the center of masses of the nucleus and the electron cloud, resulting in a polarized atom. On the other hand, a few molecules, like water,...
367
00:59Propagation of Uncertainty from Random Error
654
An experiment often consists of more than a single step. In this case, measurements at each step give rise to uncertainty. Because the measurements occur in successive steps, the uncertainty in one step necessarily contributes to that in the subsequent step. As we perform statistical analysis on these types of experiments, we must learn to account for the propagation of uncertainty from one step to the next. The propagation of uncertainty depends on the type of arithmetic operation performed on...
654
01:10Propagation of Uncertainty from Systematic Error
485
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
485