Related Experiment Video

Updated: Jun 8, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.2K

Prevalence of masked hypertension in children with chronic kidney disease: a cross-sectional study

Nasmin Ak1, Amit Kumar Satapathy2, Joseph John1

  • 1Department of Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, 751019, Odisha, India.

Pediatric Nephrology (Berlin, Germany)
|November 1, 2024
PubMed

Insights

Masked hypertension is common in children with chronic kidney disease (CKD). Ambulatory blood pressure monitoring (ABPM) effectively identifies these cases, highlighting the need for updated hypertension guidelines in pediatric CKD management.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Health in Chronic Disease
  • Diagnostic Tools in Hypertension

Background:

  • Hypertension is a major risk factor for chronic kidney disease (CKD) progression.
  • Masked hypertension, normal in-office readings but elevated out-of-office, is a concern in pediatric CKD.
  • Ambulatory blood pressure monitoring (ABPM) is a key tool for detecting masked hypertension.

Purpose of the Study:

  • To compare the prevalence of masked hypertension in pediatric CKD patients using 2014 and 2022 American Heart Association (AHA) guidelines.
  • To assess the diagnostic utility of ABPM in identifying masked hypertension in this population.

Main Methods:

  • A cross-sectional study involving 138 children (aged 5-15 years) with CKD.
  • Utilized 24-hour ABPM to assess blood pressure.
  • Calculated left ventricular mass (LVM) via echocardiography and pulse wave velocity (PWV).

Main Results:

  • The 2022 AHA ABPM guidelines identified a masked hypertension prevalence of 29.7% in pediatric CKD patients.
  • This represents a significant increase of 17.4% compared to the 2014 guidelines.
  • Overall hypertension prevalence detected by ABPM was 48.5%, an increase of 22.5%.

Conclusions:

  • Masked hypertension is prevalent in children with CKD.
  • ABPM is crucial for uncovering masked hypertension in this vulnerable group.
  • Updated guidelines reveal a higher burden of hypertension, emphasizing the need for vigilant monitoring.
Abstract

Keywords:
ABPMCKDChildrenHypertensionMasked hypertension

More Related Videos

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis08:21

A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis

Published on: October 26, 2020

4.7K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

498

Related Concept Videos

Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
Antihypertensive Drugs: Potassium-Sparing Diuretics01:28

Antihypertensive Drugs: Potassium-Sparing Diuretics

Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
463
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
57
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.4K
Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.2K