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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Trace elements in psoriasis presentation and treatment.

Pratiksha Patra¹, Tyler Harrison²

¹Fourth-year Medical Student, University of South Florida Morsani College of Medicine, Tampa, FL, USA. patrap@usf.edu.

Archives of Dermatological Research

|November 1, 2024

Summary

This summary is machine-generated.

Psoriasis pathogenesis may involve trace metals like zinc and calcium, which regulate cell processes and correlate with disease severity. Evaluating serum levels could guide personalized treatments for this skin condition.

Keywords:

Calcium Magnesium Psoriasis Zinc

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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Area of Science:

Dermatology
Biochemistry
Nutritional Science

Background:

Psoriasis is a chronic inflammatory skin disease with complex pathogenesis.
Trace metals play crucial roles in cellular functions and immune responses.
Existing research suggests potential links between psoriasis and mineral imbalances.

Purpose of the Study:

To systematically review the literature on the relationship between psoriasis and trace metals.
To explore the role of specific elements in psoriasis pathogenesis.
To investigate the potential of trace metals as therapeutic targets for psoriasis.

Main Methods:

Systematic literature search of PubMed, Scopus, and Embase databases.
Inclusion of articles published within the last 12 years.
Quality assessment using Boote and Biele's Literature Review Rubric.

Main Results:

Calcium, magnesium, and zinc were frequently discussed elements.
Calcium regulates cell differentiation and proliferation in psoriasis.
Zinc offers protection against oxidative stress implicated in psoriasis inflammation.
Serum calcium and zinc levels negatively correlate with plaque psoriasis severity.

Conclusions:

Psoriasis pathogenesis is influenced by trace metals, particularly calcium and zinc.
Serum level evaluation of these elements may aid in personalized treatment strategies.
Further comprehensive research is warranted to fully elucidate these relationships.