Identification and validation of CCN family genes to predict the prognosis in gastric cancer

Huanting Chen ^1,2, Xiaomin Zhang ^3,1,4, Zhe Zhang ^3,1,4

¹Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Shenzhen, 518036, China.
²Department of General Surgery, People's Hospital of Shenzhen Baoan District, Affiliated Shenzhen Baoan Hospital of Southern Medical University, Shenzhen, 518101, China.
³Department of Radiation Oncology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, 518036, Guangdong, China.
⁴Cancer Institute of Shenzhen-PKU-HKUST Medical Center, Shenzhen, 518036, China.
⁵Department of Radiation Oncology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, 518036, Guangdong, China. liuyajie_pkuszh@163.com.
⁶Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Shenzhen, 518036, China. liuyajie_pkuszh@163.com.
⁷Cancer Institute of Shenzhen-PKU-HKUST Medical Center, Shenzhen, 518036, China. liuyajie_pkuszh@163.com.
⁸Department of Radiation Oncology, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, 518036, Guangdong, China. yangmq_sysu@163.com.
⁹Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Shenzhen, 518036, China. yangmq_sysu@163.com.
¹⁰Cancer Institute of Shenzhen-PKU-HKUST Medical Center, Shenzhen, 518036, China. yangmq_sysu@163.com.

⁰Shenzhen Key Laboratory of Gastrointestinal Cancer Translational Research, Shenzhen, 518036, China.

Discover Oncology +

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November 1, 2024

View abstract on PubMed

Summary

WISP1, a member of the cellular communication network (CCN) family, is highly expressed in gastric cancer (GC) and linked to poor survival. This study identifies WISP1 as a potential prognostic marker and therapeutic target for GC.

Area Of Science

Oncology
Molecular Biology
Bioinformatics

Background

Gastric cancer (GC) is a prevalent and lethal malignancy globally.
The cellular communication network (CCN) family proteins regulate cell proliferation and differentiation.
Understanding CCN family roles is crucial for GC prognosis.

Purpose Of The Study

To conduct an integrated analysis of CCN family genes in gastric cancer.
To identify CCNs as potential prognostic predictors for GC patients.
To investigate the specific role of WISP1 in GC progression.

Main Methods

Utilized Gene Expression Omnibus (GEO) microarray datasets for differential gene expression analysis.
Performed functional enrichment and genetic alteration analysis of CCNs.
Validated WISP1 expression and function in GC cell lines.

Main Results

Identified 26 significantly upregulated genes in gastric tumor tissues.
Found CCN family genes, particularly WISP1, associated with GC prognosis.
WISP1 upregulation correlates with poor survival and advanced pathological stage in GC.
In vitro experiments showed WISP1 promotes GC cell proliferation and invasion.

Conclusions

Comprehensive bioinformatic analysis reveals significant roles for CCN genes in GC.
WISP1 emerges as a promising prognostic biomarker for gastric cancer.
WISP1 presents a potential therapeutic target for gastric cancer treatment.

Keywords:

Biomarker CCN family Gastric cancer Prognosis WISP1