Related Experiment Video

Updated: Jun 8, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
08:45

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

6.2K

G protein coupled P2Y2 receptor as a regulatory molecule in cancer progression

Wen-Jun Zhang1, Qing-Ming Shi2, Teng-Zheng Li2

  • 1Rehabilitation Medicine Department, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang City, Jiangxi province, China.

Archives of Biochemistry and Biophysics
|November 1, 2024
PubMed

Insights

The P2Y2 purinergic receptor (P2Y2 receptor) influences cancer growth and metastasis. Inhibiting P2Y2 receptor activation or expression shows potential for novel anti-cancer therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer's complex mechanisms and treatment challenges necessitate new therapeutic targets.
  • Drug resistance, metastasis, and recurrence remain significant obstacles in cancer treatment.
  • The P2Y2 purinergic receptor (P2Y2 receptor), a G protein-coupled receptor, is implicated in cancer progression.

Purpose of the Study:

  • To investigate the role of P2Y2 receptor in cancer pathology.
  • To explore P2Y2 receptor as a potential molecular target for anti-cancer therapies.
  • To review P2Y2 receptor expression patterns in various cancers.

Main Methods:

  • Review of literature on P2Y2 receptor function in cancer.
  • Analysis of signaling pathways regulated by P2Y2 receptor (e.g., calcium ion channels, PLC-PKC, PI3K/AKT).
  • Examination of therapeutic strategies involving P2Y2 receptor modulation (antagonists, expression reduction).

Main Results:

  • P2Y2 receptor activation promotes tumor cell growth and metastasis.
  • P2Y2 receptor signaling pathways are crucial in cancer progression.
  • Inhibition of P2Y2 receptor activity or expression exhibits anti-tumor effects.

Conclusions:

  • The P2Y2 receptor is a key regulator of cancer progression.
  • Targeting P2Y2 receptor presents a promising strategy for developing novel anti-cancer treatments.
  • Understanding P2Y2 receptor expression patterns is vital for its therapeutic application.
Keywords:
AgonistAntagonistCancerP2Y2 receptor

More Related Videos

RhoC GTPase Activation Assay09:58

RhoC GTPase Activation Assay

Published on: August 22, 2010

12.4K
Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay13:51

Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay

Published on: November 11, 2018

9.8K

Related Concept Videos

mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K
Amplifying Signals via Second Messengers01:15

Amplifying Signals via Second Messengers

Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
6.8K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
GPCRs Regulate Adenylyl Cylase Activity01:09

GPCRs Regulate Adenylyl Cylase Activity

Some GPCRs transmit signals through adenylyl cyclase (AC), a transmembrane enzyme. AC helps synthesize second messenger cyclic adenosine monophosphate (cAMP). AC catalyzes cyclization reaction and converts ATP to cAMP by releasing a pyrophosphate. The pyrophosphate is further hydrolyzed to phosphate by the enzyme pyrophosphatase, which drives cAMP synthesis to completion. However, cAMP is rapidly degraded to 5′ AMP by the enzymes phosphodiesterase (PDE), preventing overstimulation of...
5.3K
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
11.4K