Related Experiment Video

Updated: Jun 8, 2025

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis
09:44

Small-Scale Plasma Membrane Preparation for the Analysis of Candida albicans Cdr1-mGFPHis

Published on: June 13, 2021

2.7K

Update on the structure and function of Candida albicans drug efflux protein, Cdr1

Chibuike Ibe1, Carolina H Pohl1

  • 1Department of Microbiology and Biochemistry, University of the Free State, PO Box 339, Bloemfontein, 9301, South Africa.

Fungal Genetics and Biology : FG & B
|November 1, 2024
PubMed

Insights

Candida albicans can resist antifungal drugs through efflux pumps like Cdr1. Understanding the structure and function of these ATP binding cassette transporters is crucial for developing new antifungal therapies.

Area of Science:

  • Medical Mycology
  • Molecular Biology
  • Biochemistry

Background:

  • Candida albicans is a significant human pathogen.
  • Antifungal drug resistance, particularly to azoles, is a growing clinical concern.
  • ATP binding cassette (ABC) transporters, such as Cdr1, are key mediators of multidrug resistance in C. albicans.

Purpose of the Study:

  • To review and summarize existing knowledge on the structure and function of the Cdr1 transporter.
  • To highlight critical areas for future research into multidrug resistance mechanisms.

Main Methods:

  • Literature review of studies on Cdr1 structure, binding, function, and regulation.
  • Synthesis of findings from various research investigations.

Main Results:

  • Cdr1 is an important efflux pump contributing to azole resistance in Candida albicans.
  • Extensive research has elucidated aspects of Cdr1's structural organization and functional mechanisms.
  • Understanding Cdr1's regulation is vital for combating drug resistance.

Conclusions:

  • Cdr1 plays a critical role in Candida albicans antifungal drug resistance.
  • Further research into multidrug ABC transporters like Cdr1 is essential for therapeutic advancements.
  • Targeting Cdr1 function may offer strategies to overcome antifungal resistance.
Keywords:
ATP binding cassette transportersCandida albicansDrug resistance

More Related Videos

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

13.7K
Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

6.9K

Related Concept Videos

Carrier-Mediated Transport01:06

Carrier-Mediated Transport

Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
279
ABC Transporters: Exporter01:31

ABC Transporters: Exporter

ATP-binding cassette or ABC transporter is the largest superfamily of integral membrane proteins. The transporters have transmembrane-binding domains (TMDs) and nucleotide-binding domains (NBDs). The TMDs are specific to their substrates, whereas the NBDs are similar to engines that complete ATP hydrolysis to complete the substrate transport. They can be full transporters consisting of two TMDs and NBDs, half transporters with one TMD and NBD, while some encoded with a single TMD or NBD are...
4.2K
Facilitated Diffusion01:16

Facilitated Diffusion

The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
316
ABC Transporters: Importer01:27

ABC Transporters: Importer

ATP-binding cassette or ABC transporters are a class of ATP-driven pumps that hydrolyze ATP to move solutes across the membrane. They can be grouped into importers and exporters. While exporters are present in all domains of life, importers exist only in bacteria and some plants.
In bacteria, based on the number of transmembrane helices and the chemical nature of their substrates, the ABC importers can be divided into three types:
2.7K
The ADP/ATP Carrier Protein01:42

The ADP/ATP Carrier Protein

ADP/ATP carrier or AAC protein is the most abundant carrier protein in the inner mitochondrial membrane. It transports large quantities of ADP and ATP, equivalent to the average human body weight, every day. Among other transporters, ACC protein is one of the best-studied members of the mitochondrial carrier protein family. The ADP/ATP carrier protein comprises two transmembrane helices connected to a loop and a single alpha-helix on the matrix side. It switches between two conformational...
3.2K
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
3.5K