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Author Spotlight: Transmitochondrial Cybrid Generation Using Cancer Cell Lines
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Canine Mammary Tumours (CMTs) exploit mitochondrial cholesterol for aggressive reprogramming.

Liana Hardy1, Brindha Kannan2, Manuel Rigon2

  • 1Department of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London NW01 TU, United Kingdom.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|November 1, 2024
PubMed
Summary

The mitochondrial translocator protein (TSPO) promotes canine mammary tumor (CMT) aggressiveness and Tamoxifen resistance by facilitating cholesterol handling. Targeting TSPO may improve cancer therapies and diagnostics.

Keywords:
Canine Mammary Tumours (CMTs)CholesterolMitochondriaTSPOTamoxifene

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