Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantifying treatment-related travel burden and its association with mortality in pediatric cancer: An analysis of state cancer registry data.

Cancer epidemiology·2026
Same author

Polarisome core component FgPea2 regulates FgBoi2-mediated polarized growth, pathogenicity and environmental stress in Fusarium graminearum.

Stress biology·2026
Same author

Genetic diversity analysis and core collection construction of Macadamia spp. from Yunnan using fourfold degenerate SNP sites.

BMC plant biology·2026
Same author

Case Report: Extracorporeal membrane oxygenation in acute coronary syndrome: a rare case of massive left ventricular thrombus.

Frontiers in cardiovascular medicine·2026
Same author

Exploring the Differences in Alkaloids of Fritillariae Thunbergii Bulbus From Different Regions Using Liquid Chromatography-Mass Spectrometry and Chemometrics.

Chemistry & biodiversity·2026
Same author

A comprehensive narrative review of <i>Epimedium</i> and its bioactive compounds in respiratory diseases.

Journal of pharmaceutical analysis·2026

Related Experiment Video

Updated: Jun 8, 2025

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.8K

Polymeric artificial heart valves derived from modified diol-based polycarbonate polyurethanes.

Yage Hu1, Yao Xiong1, Yuan Wei1

  • 1National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu 610064, PR China.

Acta Biomaterialia
|November 1, 2024
PubMed
Summary

New polycarbonate silicone polyurethanes (SiPCUs) enhance artificial heart valve materials. These SiPCUs offer improved biostability, biocompatibility, and mechanical performance, showing promise over current valve technologies.

Keywords:
BiocompatibilityBiostabilityHeart valvesModified macromolecular diolPolycarbonate polyurethane

More Related Videos

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.5K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K

Related Experiment Videos

Last Updated: Jun 8, 2025

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves
11:12

Protocol for Relative Hydrodynamic Assessment of Tri-leaflet Polymer Valves

Published on: October 17, 2013

13.8K
Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

12.5K
Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
05:31

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model

Published on: June 8, 2022

2.8K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Cardiovascular Engineering

Background:

  • Artificial heart valves are critical for treating valvular heart disease.
  • Polyurethane-based materials offer durability, biocompatibility, and tunable properties for valve applications.
  • Existing materials face limitations in biostability, mechanical integrity post-degradation, and biocompatibility.

Purpose of the Study:

  • To synthesize and characterize novel polycarbonate silicone polyurethanes (SiPCUs) for artificial heart valve leaflets.
  • To improve the biostability, mechanical properties, and biocompatibility of polyurethane elastomers.
  • To evaluate the performance of SiPCUs against current bioprosthetic heart valve materials.

Main Methods:

  • Synthesized SiPCUs by incorporating 4,4'-dicyclohexylmethane diisocyanate (HMDI) into the soft segment (PCDL) and using HMDI with chain extenders (1,4-butanediol, BHTD) for the hard segment.
  • Characterized physicochemical properties, oxidative degradation stability, and mechanical performance post-degradation.
  • Assessed biocompatibility, thromboresistance, calcification, and endothelial cell adhesion compared to Glut-PP.
  • Fabricated and tested valve prototypes for hemodynamic performance.

Main Results:

  • The synthesized PHC-PCUB demonstrated improved phase mixing, reducing issues from polydimethylsiloxane (PDMS) introduction.
  • Materials exhibited good physicochemical properties, long-term oxidative degradation stability, and minimal mechanical loss after degradation.
  • PHC-PCUB showed enhanced biocompatibility, superior thromboresistance, reduced calcification, and increased endothelial cell adhesion compared to Glut-PP.
  • Valve prototypes exhibited improved hemodynamic performance.

Conclusions:

  • Polycarbonate silicone polyurethanes (SiPCUs) represent a promising advanced material for artificial heart valve leaflets.
  • The developed SiPCUs offer a superior combination of biostability, mechanical resilience, and biocompatibility.
  • These materials effectively address limitations of current mechanical and bioprosthetic heart valves, paving the way for improved clinical outcomes.