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Updated: Jun 8, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

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Correlations between the long noncoding RNA MEG3 and clinical characteristics for diabetic kidney disease in type 2

Ke-Hsin Ting1,2,3,4, Po-Jen Yang5,6, Po-Yu Tsai4,7

  • 1Division of Cardiology, Department of Internal Medicine, Yunlin Branch, Changhua Christian Hospital, Yunlin, Taiwan.

Diabetology & Metabolic Syndrome
|November 2, 2024
PubMed
Abstract

Insights

The MEG3 SNP rs3087918 is less common in patients with diabetic kidney disease (DKD). This single-nucleotide polymorphism (SNP) is also linked to lower glycated hemoglobin (HbA1c) levels in type 2 diabetes mellitus (T2DM) patients.

Area of Science:

  • Genetics and Molecular Biology
  • Nephrology
  • Endocrinology

Background:

  • Diabetic kidney disease (DKD) is a significant complication of type 2 diabetes mellitus (T2DM), contributing to systemic inflammation.
  • Maternally expressed gene 3 (MEG3), a tumor suppressor, plays a role in regulating inflammation.

Purpose of the Study:

  • To investigate the association between DKD and the prevalence of single-nucleotide polymorphisms (SNPs) in the MEG3 gene.
  • To explore the relationship between MEG3 SNPs and glycemic control (HbA1c) in T2DM patients.

Main Methods:

  • Genotyping of five MEG3 SNPs (rs4081134, rs10144253, rs7158663, rs3087918, rs11160608) in 706 DKD patients and 735 non-DKD controls using TaqMan allelic discrimination.
  • Statistical analysis to determine the prevalence of genotypes in DKD and non-DKD groups, and their association with clinical parameters.

Main Results:

  • The GG genotype of MEG3 SNP rs3087918 was significantly less prevalent in the DKD group compared to the wild-type genotype.
  • In subgroups of pre-ESRD DKD patients and male DKD patients, the GG genotype of rs3087918 was also significantly less prevalent.
  • Higher glycated hemoglobin (HbA1c) levels were observed in T2DM patients, particularly males, with the wild-type genotype of MEG3 SNP rs3087918.

Conclusions:

  • MEG3 SNP rs3087918 is significantly less prevalent in individuals with diabetic kidney disease.
  • The presence of MEG3 SNP rs3087918 is associated with improved glycemic control, indicated by lower HbA1c levels in T2DM patients.
Keywords:
Diabetic kidney diseaseEnd stage renal diseaseMEG3MaleSingle-nucleotide polymorphisms

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