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Transcutaneous Auricular Vagus Nerve Stimulation for Visually Induced Motion Sickness: An eLORETA Study.

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Gastroenterology

Background:

  • Motion sickness is a poorly understood syndrome with diverse symptoms.
  • Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique with therapeutic potential.
  • The effects of taVNS on brain activity during motion-induced nausea are not well-characterized.

Purpose of the Study:

  • To investigate the impact of taVNS on brain function during motion-induced nausea.
  • To identify specific brain regions modulated by taVNS in response to nauseogenic stimuli.
  • To correlate taVNS-induced neural changes with reductions in motion sickness symptoms.

Main Methods:

  • A randomized, sham-controlled crossover study involving 42 healthy participants.
  • 64-channel electroencephalography (EEG) recordings during visual motion stimulation with concurrent taVNS or sham stimulation.
  • Analysis of cortical neuronal generators using exact low-resolution brain electromagnetic tomography (eLORETA).

Main Results:

  • Both sham and taVNS increased insula activation compared to baseline.
  • taVNS uniquely augmented activity in the middle frontal gyrus and middle occipital gyrus during stimulation.
  • taVNS led to activation in the supramarginal, parahippocampal, and precentral gyri post-stimulation.
  • taVNS significantly reduced motion sickness symptoms, correlating with observed neural activation.

Conclusions:

  • taVNS modulates specific brain regions, including the middle frontal and occipital gyri, during and after exposure to nauseogenic stimuli.
  • taVNS demonstrates efficacy in reducing motion sickness symptoms.
  • These findings support taVNS as a potential therapeutic tool for managing motion sickness.