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Related Concept Videos

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  3. Histopathological Prognostic Factors Of Surgically Treated Hpv-associated Oropharyngeal Squamous Cell Carcinoma: A Systematic Review And Meta-analysis.
  1. Home
  3. Histopathological Prognostic Factors Of Surgically Treated Hpv-associated Oropharyngeal Squamous Cell Carcinoma: A Systematic Review And Meta-analysis.

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Histopathological Prognostic Factors of Surgically Treated HPV-Associated Oropharyngeal Squamous Cell Carcinoma: A

Branden Qi Yu Chua1, Vanessa Wei Shan Chong1, Hanis Binte Abdul Kadir2

  • 1Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.

Annals of Surgical Oncology
|November 2, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
Extranodal extensionHuman papillomavirusLymphovascular invasionMarginMeta-analysisOropharyngeal cancerPrognosisTNM staging

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Extra-nodal extension (ENE), advanced pT stage, positive margins, and lymphovascular invasion are key adverse prognostic markers in surgically treated HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). Careful evaluation of these factors is crucial for optimal patient selection.

Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) incidence is increasing.
  • HPV-positive OPSCC generally has a better survival rate than HPV-negative OPSCC.
  • Established adverse pathological features in HPV-negative OPSCC lack validation in HPV-positive OPSCC.

Purpose of the Study:

  • To determine the prognostic significance of specific adverse histological features in surgically treated HPV-positive OPSCC.
  • To pool existing evidence to validate prognostic markers for HPV-positive OPSCC.
  • To identify histological factors impacting outcomes in HPV-positive OPSCC patients.

Main Methods:

  • Meta-analysis conducted following PRISMA guidelines.
  • Systematic literature search of PubMed, Web of Science, and Embase databases.
  • Inclusion of studies evaluating 13 histopathological prognostic factors in surgically treated HPV-associated OPSCC.

    • Main Results:

    • Extra-nodal extension (ENE) and advanced pT stage significantly correlate with poorer overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS).
    • Lymphovascular invasion and positive surgical margins were also found to significantly worsen overall survival (OS).
    • Data analysis involved 32 studies with a total of 31,535 patients.

    Conclusions:

    • Extra-nodal extension (ENE), advanced pT stage, positive margins, and lymphovascular invasion are confirmed adverse histological prognostic markers in HPV-positive OPSCC.
    • These identified factors require careful evaluation for optimal patient selection in surgical treatment.
    • The findings aid in refining treatment strategies for HPV-positive OPSCC.