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Integrated substrate utilization by perinatal lung.

C E Patterson, M V Koniki, W M Selig

    Experimental Lung Research
    |January 1, 1986
    PubMed
    Summary
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    Lactate is a crucial substrate for perinatal rat lung development, fueling fatty acid synthesis and CO2 production during lung maturation. Glucose plays a lesser role, with lactate significantly impacting lipid metabolism.

    Area of Science:

    • Perinatal Biology
    • Biochemistry
    • Respiratory Physiology

    Background:

    • Lung maturation involves significant metabolic shifts.
    • Substrate utilization by the developing lung is critical for phospholipid synthesis.
    • Understanding nutrient pathways is key to perinatal lung development.

    Purpose of the Study:

    • To investigate substrate utilization patterns in the perinatal rat lung.
    • To determine the functional relationship of substrates during lung maturation.
    • To identify key substrates for lung lipid synthesis and energy production.

    Main Methods:

    • Utilized 14C-labeled substrates (glucose, lactate, glycerol, beta-hydroxybutyrate, palmitate, choline).
    • Measured substrate incorporation into lung lipids and disaturated phosphatidylcholine (DSPC).

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  • Analyzed substrate contribution to de novo fatty acid synthesis and CO2 production.

    • Main Results:

    • Maximal substrate incorporation into lung lipids and DSPC occurred one day before birth.
    • Lactate provided 60% of carbons for fatty acid synthesis, compared to 9% from glucose.
    • Lactate produced 5 times more CO2 than glucose and altered glucose metabolism in lung lipids.

    Conclusions:

    • Lactate is a key substrate for perinatal rat lung development.
    • Lactate significantly influences fatty acid synthesis and energy metabolism.
    • Glycerol and palmitate are less important energy fuels during this period.