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Updated: Jul 23, 2026
In Vitro Modeling of Cancerous Neural Invasion: The Dorsal Root Ganglion Model
Published on: April 12, 2016
Perineural invasion and laryngeal squamous cell carcinoma: a systematic review
Debora Modelli Vianna Ocampo Quintana1, Rogerio Aparecido Dedivitis2, Luiz Paulo Kowalski2
1Hospital Heliópolis, Departamento de Cirurgia de Cabeça e Pescoço, São Paulo, SP, Brazil.
Objectives:
Several studies have evaluated the prognostic significance of Perineural Invasion (IPN) in laryngeal cancer; however, the results are non-conclusive. Therefore, we conducted a meta-analysis aiming to identify the prognostic value of IPN in laryngeal cancer.
Methods:
A literature review was performed, searching MedLine via PubMed, Scielo, Lilacs, Cochrane and Websco. RevMan 5.4 was used for the statistical analysis.
Results:
A total of 19 laryngeal cancer studies were included. The results indicate that IPN in laryngeal cancer shows 2-year survival with RR 0.71 (0.59‒0.86); disease-free survival RR 0.51 (0.14-1.95); and locoregional recurrence RR 1.71 (1.25-2.35).
Conclusion:
IPN is a negative prognostic factor in laryngeal cancer.
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