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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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ACR Appropriateness Criteria® Multiple Gestations: 2024 Update.

, Priyanka Jha1, Vickie A Feldstein2

  • 1Stanford University School of Medicine, Stanford, California.

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|November 2, 2024
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Rising twin pregnancies necessitate clear imaging guidelines. This document provides evidence-based ultrasound and MRI recommendations for multiple gestations, crucial for risk assessment and management.

Keywords:
AUCAppropriateness CriteriaDoppler ultrasoundappropriate use criteriadichorionicmonochorionicmultiple gestationstwin pregnancyultrasound

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Area of Science:

  • Radiology
  • Maternal-Fetal Medicine
  • Obstetrics

Background:

  • The incidence of twin pregnancies is increasing, primarily due to assisted reproductive technologies.
  • Ultrasound is essential for determining chorionicity and amnionicity in multiple gestations, predicting risks and guiding follow-up.
  • Multiple gestations require more frequent imaging than singleton pregnancies, including dating, nuchal translucency, anatomy, and surveillance scans.

Purpose of the Study:

  • To clarify appropriate imaging guidelines for multiple gestations across seven clinical scenarios.
  • To provide evidence-based recommendations for initial and follow-up imaging, growth, and surveillance.
  • To address uncomplicated and complicated multiple gestations, including those with fetal abnormalities or discordance.

Main Methods:

  • Development of evidence-based guidelines using systematic analysis of peer-reviewed literature.
  • Adaptation of established methodology principles like Grading of Recommendations Assessment, Development, and Evaluation (GRADE).
  • Utilization of the RAND/UCLA Appropriateness Method for determining the suitability of imaging procedures, with expert opinion used when literature is limited.

Main Results:

  • The document outlines specific imaging guidelines for various multiple gestation scenarios.
  • Recommendations cover initial assessments, ongoing surveillance, and management of complications.
  • Guidelines are designed to optimize clinical and imaging follow-up for improved patient outcomes.

Conclusions:

  • Appropriate imaging guidelines are critical for managing the increasing number of multiple gestations.
  • These evidence-based recommendations aid in risk stratification and clinical decision-making.
  • The guidelines support standardized care for multiple pregnancies, ensuring timely and necessary imaging examinations.