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Updated: Jun 8, 2025

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
[CT imaging of chronic obstructive pulmonary disease: What aspects and what role?]
G Dournes1, M Zysman1, I Benlala1
1Centre de recherche cardio-thoracique de Bordeaux, U1045, CIC 1401, université de Bordeaux, Inserm, 33600 Pessac, France; Service d'imagerie thoracique et cardiovasculaire, service des maladies respiratoires, service d'exploration fonctionnelle respiratoire, Paediatric Cystic Fibrosis Reference Center (CRCM), CIC 1401, CHU de Bordeaux, 33600 Pessac, France; Centre de recherche cardio-thoracique de Bordeaux, CIC 1401, Inserm, U1045, 33600 Pessac, France.
Abstract:
Chronic obstructive pulmonary disease (COPD), commonly defined as irreversible airflow limitation, is associated with specific morphological changes involving all three parts of the lung, namely the bronchi, parenchyma and pulmonary vessels. In vivo imaging, with its ability to describe the different types of lung alterations and their regional distribution, helps to elucidate the relationship between lung structure and respiratory function. High-resolution computed tomography (CT) of the lung is the imaging modality best suited to assessing the pathological changes associated with airflow obstruction occurring in COPD. Over the last few decades, numerous studies have demonstrated the role of CT as a morphological and functional method conducive to the phenotyping of COPD patients. This review proposes to examine the data on CT imaging of COPD with a critical approach to recent data, and to determine the extent to which CT could be integrated into care or clinical research on patients with this/these disease(s).
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