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Related Experiment Video

Updated: Jun 8, 2025

Author Spotlight: Advancing Hepatobiliary and Pancreatic Tumor Treatment with Minimally Invasive Surgical Techniques
03:33

Author Spotlight: Advancing Hepatobiliary and Pancreatic Tumor Treatment with Minimally Invasive Surgical Techniques

Published on: September 27, 2024

761

Laparoscopic versus open surgery for liver resection: a multicenter cohort study.

Yesheng Li1,2, Longrong Wang1, Yibin Guo3

  • 1Department of Hepatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.

Scientific Reports
|November 3, 2024
PubMed
Summary
This summary is machine-generated.

Laparoscopic liver resection (LLR) shows fewer major complications compared to open liver resection (OLR). Survival outcomes were similar for both LLR and OLR in patients with primary malignant liver tumors.

Keywords:
ComplicationsHepatectomyLaparoscopesLiver neoplasms

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Area of Science:

  • Hepatobiliary Surgery
  • Minimally Invasive Surgery
  • Surgical Oncology

Background:

  • Laparoscopic liver resection (LLR) versus open liver resection (OLR) for primary malignant liver tumors remains debated.
  • Assessing perioperative and survival outcomes is crucial for surgical decision-making.

Purpose of the Study:

  • To evaluate and compare perioperative complications and survival outcomes between LLR and OLR.
  • To identify patient subgroups that may benefit more from LLR.

Main Methods:

  • Retrospective analysis of 5886 patients undergoing liver resection (1991 LLR, 3895 OLR) across three high-volume expert centers.
  • Multivariable logistic regression for major complications (Clavien-Dindo Classification grade ≥ II).
  • Multivariable Cox proportional hazards regression for survival analysis.

Main Results:

  • LLR was associated with a significantly lower rate of major complications (OR = 0.56, P < 0.001).
  • LLR benefits were more pronounced in women, non-drinkers, patients without prior abdominal surgery, and those with normal platelet counts.
  • Overall survival did not significantly differ between LLR and OLR for primary malignant liver tumors (P > 0.05).

Conclusions:

  • LLR is associated with reduced major complications compared to OLR.
  • LLR offers a safe and effective approach for primary malignant liver tumors, with comparable survival to OLR.
  • Patient-specific factors influence the benefits of LLR regarding complication rates.