Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential stem-like potential of naïve and memory CD8 T cells after chronic infection.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Preferential medial claustrum input and orbitofrontal output of the rostral-to-stratum claustrum in rats.

Biochemical and biophysical research communications·2026
Same author

Computational mechanisms for temporal integration in the anterior claustrum.

eLife·2026
Same author

Selective depletion of virus-specific CD8 T cells from the liver after PD-1 therapy with Fc-intact antibody during chronic infection.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Association Between the Persistency and Severity of Mitral Regurgitation and the Hematologic Z-Values of Inflammatory Biomarkers in Kawasaki Disease.

Korean circulation journal·2026
Same author

Feed-forward inhibitory circuit from the anterior cingulate cortex regulates periaqueductal gray's panic-like responses.

Brain structure & function·2025

Related Experiment Video

Updated: May 12, 2026

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
09:43

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Published on: August 10, 2014

Protocol for preparing and using a task to study "delayed safety-seeking behavior" in rats.

Junghwa Lee1, Sukwoo Choi1

  • 1School of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.

STAR Protocols
|November 3, 2024
PubMed
Summary

Researchers developed a novel delayed safety-seeking task for rats, enabling the study of defensive behaviors without trial and error. This new animal model allows for in vivo recordings and optogenetics in novel situations.

Keywords:
behaviormodel organismsneuroscience

More Related Videos

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

An Open-Source, Fully Customizable 5-Choice Serial Reaction Time Task Toolbox for Automated Behavioral Training of Rodents
09:39

An Open-Source, Fully Customizable 5-Choice Serial Reaction Time Task Toolbox for Automated Behavioral Training of Rodents

Published on: January 19, 2022

Related Experiment Videos

Last Updated: May 12, 2026

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents
09:43

The 5-Choice Serial Reaction Time Task: A Task of Attention and Impulse Control for Rodents

Published on: August 10, 2014

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats
09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

An Open-Source, Fully Customizable 5-Choice Serial Reaction Time Task Toolbox for Automated Behavioral Training of Rodents
09:39

An Open-Source, Fully Customizable 5-Choice Serial Reaction Time Task Toolbox for Automated Behavioral Training of Rodents

Published on: January 19, 2022

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Cognitive Science

Background:

  • Predicting action outcomes in novel situations is crucial for survival.
  • Defensive behaviors are key to understanding adaptive responses.
  • Existing animal models lack the capacity for studying predictive defensive behaviors without trial and error.

Purpose of the Study:

  • To present a protocol for a delayed safety-seeking task in rats.
  • To enable the study of predictive defensive behaviors in novel environments.
  • To provide a foundation for future research on decision-making under uncertainty.

Main Methods:

  • Construction of a specialized two-compartment chamber.
  • Development of a delayed safety-seeking task protocol.
  • Integration of in vivo recordings and optogenetics for neural analysis.

Main Results:

  • The protocol facilitates temporary information holding for future safety-seeking in rats.
  • The task allows for the examination of defensive behaviors in predictable and unpredictable scenarios.
  • The methodology supports detailed investigation of neural mechanisms underlying defensive behaviors.

Conclusions:

  • The delayed safety-seeking task is a valuable new animal model for studying predictive defensive behaviors.
  • This protocol advances research into how animals learn and adapt in novel situations.
  • The model offers a platform for exploring the neural basis of risk assessment and avoidance.