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Updated: Jun 8, 2025

Utility of Dissociated Intrinsic Hand Muscle Atrophy in the Diagnosis of Amyotrophic Lateral Sclerosis
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F-waves responses derived from low-intensity electrical stimulation: A method to explore split-hand pathogenesis.

Miguel Lopes1, Michael Swash2, Mamede de Carvalho3

  • 1Institute of Physiology, Instituto de Medicina Molecular João Lobo Antunes, Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

Neurophysiologie Clinique = Clinical Neurophysiology
|November 3, 2024
PubMed
Summary
This summary is machine-generated.

This study used low-intensity F-wave stimulation to reveal physiological differences in hand muscles, suggesting distinct spinal motoneuron pool properties in the abductor digiti minimi (ADM) compared to other muscles.

Keywords:
Amyotrophic lateral sclerosisF-wavesHand musclesMotor unitsSplit-hand

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Area of Science:

  • Neurophysiology
  • Motor Neuron Excitability
  • Clinical Electrophysiology

Background:

  • Split-hand syndrome in amyotrophic lateral sclerosis (ALS) shows differential hand muscle atrophy.
  • Understanding physiological differences in hand muscles is crucial for ALS research.
  • F-wave stimulation assesses spinal motoneuron excitability.

Purpose of the Study:

  • To investigate physiological differences between hand muscles using low-intensity F-wave stimulation.
  • To assess spinal motoneuron excitability in abductor pollicis brevis (APB), first dorsal interosseous (FDI), and abductor digiti minimi (ADM).

Main Methods:

  • Recruited 36 healthy volunteers.
  • Recorded F-waves from APB, FDI, and ADM using low-intensity and supramaximal stimulation.
  • Evaluated F-wave parameters including latency, chronodispersion, persistence, amplitude, and F/CMAP amplitude ratio.

Main Results:

  • Low-intensity stimulation yielded lower F-wave amplitude and persistence, and higher F/CMAP ratios.
  • No significant differences in F-wave latencies or chronodispersion were observed.
  • ADM and APB showed higher F-wave persistence and F/CMAP ratios compared to FDI; ADM had more F-wave repeaters.

Conclusions:

  • A small number of low-intensity stimuli is sufficient for studying F-wave latencies and chronodispersion.
  • Distinct physiological properties exist within the spinal motoneuron pool of the ADM compared to other hand muscles.