Pleuropulmonary reactions in patients on bromocriptine treatment

Pleural thickening was observed in 4 patients during treatment with bromocriptine in dosages of 10-90 mg/day. Three patients who received at least 50 mg/day developed respiratory symptoms, elevated ESR and pleural effusion, which were normalized after withdrawal of the drug or reduction of the dosage. However, the pleural thickening was not fully reversible in any of the patients.