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Apoptotic cell death during regressive changes in salivary glands: A morphological perspective
Shigeru Takahashi1, Akihiro Nezu2, Akihiko Tanimura2
1Department of Oral Functional Anatomy, Hokkaido University Faculty of Dental Medicine, Kita 13, Nishi 7, Kita-ku, Sapporo, 060-8586, Japan.
Journal of Oral Biosciences
|November 3, 2024
Summary
Apoptosis, programmed cell death, eliminates salivary gland acinar cells during tissue regression. This active process prevents complete gland destruction in conditions like obstructive sialadenitis and aging.
Area of Science:
- Cell Biology
- Histopathology
- Regenerative Medicine
Background:
- Apoptosis was initially identified using transmission electron microscopy.
- Morphological techniques have since revealed apoptosis's role in various pathological conditions.
- This review focuses on morphological studies of apoptotic cell death in salivary gland regression.
Purpose of the Study:
- To review experimental studies on apoptotic cell death in salivary glands.
- To focus on morphological observations of apoptosis during salivary gland regressive changes.
Main Methods:
- Review of experimental studies.
- Focus on morphological observations of apoptotic cell death.
- Analysis of salivary gland regressive changes.
Main Results:
- Apoptosis eliminates acinar cells during salivary gland atrophy.
- Obstructive sialadenitis shows acinar cell loss due to apoptosis.
- Apoptosis contributes to age-related salivary gland changes and regression in hypertrophic/irradiated glands.
Conclusions:
- Apoptosis actively eliminates salivary gland acinar cells during atrophy.
- This programmed cell death prevents complete gland destruction.
- Further research is needed to fully understand apoptosis's role in salivary gland regression.
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