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Corrigendum to "Management of atypical cartilaginous tumors (ACT): An Italian Sarcoma Group (ISG) consensus document" [Crit. Rev. Oncol. Hematol. 223 (2026) 105358].

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Sinonasal Adenocarcinomas: An Update.

Giorgia Arcovito1, Alessandro Franchi1

  • 1Department of Translational Research, Section of Pathology, University of Pisa 56124, Italy.

Surgical Pathology Clinics
|November 3, 2024
PubMed
Summary
This summary is machine-generated.

Adenocarcinomas are the second most common sinonasal malignancy. This study explores the diverse subtypes, including intestinal-type adenocarcinoma (ITAC) and non-intestinal-type adenocarcinomas (non-ITACs), highlighting their distinct features and diagnostic challenges.

Keywords:
AdenocarcinomaIntestinal-type adenocarcinomaNasal cavityNonintestinal type adenocarcinoma

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Area of Science:

  • Pathology
  • Oncology

Background:

  • Adenocarcinomas represent the second most frequent sinonasal malignancy, following squamous cell carcinoma.
  • Sinonasal adenocarcinomas exhibit significant heterogeneity, encompassing intestinal-type (ITAC), non-intestinal-type (non-ITAC), and salivary-type subtypes.

Purpose of the Study:

  • To delineate the histopathological characteristics of various sinonasal adenocarcinoma subtypes.
  • To clarify the diagnostic criteria and challenges associated with non-ITACs.

Main Methods:

  • Histopathological review of sinonasal adenocarcinoma cases.
  • Comparative analysis of ITAC and non-ITAC features.
  • Literature review on adenocarcinoma classification.

Main Results:

  • Intestinal-type adenocarcinoma (ITAC) displays features analogous to gastrointestinal adenocarcinomas, including tubulo-papillary and colonic patterns, with mucin production in 20-25% of cases.
  • Non-ITACs lack specific intestinal or salivary differentiation, often posing diagnostic challenges as a diagnosis of exclusion.
  • Salivary-type adenocarcinomas represent a distinct category within sinonasal adenocarcinomas.

Conclusions:

  • Sinonasal adenocarcinomas are a diverse group requiring precise classification.
  • Further research is needed to establish robust histopathological and molecular definitions for non-ITACs.
  • Accurate diagnosis is crucial for appropriate patient management and therapeutic strategies.