Related Experiment Video
Updated: Jun 8, 2025
Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis
Published on: February 9, 2024
Multiparameter and Ultrasound Radiomics Nomogram to Predict the Aggressiveness of Papillary Thyroid Carcinomas: A
1Department of Ultrasound, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, China (F.L., Y.D., L.L., J.M., M.Y., R.W.).
Rationale And Objectives:
To construct a multiparameter radiomics nomogram based on ultrasound (US) to predict the aggressiveness of thyroid papillary carcinoma (PTC).
Materials And Methods:
In total, 471 consecutive patients from three institutions were included in this study. Among them, patients from institution 1 were used for training (n = 294) and internal validation (n = 92), while 85 patients from institution 2 and institution 3 were used for external validation. Radiomics features were extracted from the conventional US. The least absolute shrinkage was employed to select the most relevant features for the aggressiveness of PTC, along with the maximum relevance minimum redundancy algorithm and selection operator. These features were then used to construct the radiomics signature (RS). Subsequently, relevant multiparameter ultrasound (MPUS) features from shear-wave elastic (SWE) and strain elastography (SE) will be extracted using multivariable logistic regression. The final radionics nomogram was conducted using the RS, clinical information, and conventional US and MPUS features. The receiver operating characteristic (ROC), calibration, and decision curves were used to evaluate the performance of the nomogram.
Results:
Multivariable logistic regression analysis indicated that age, nodule size, capsule abutment, SWV tumor, and RS were independent predictors of the aggressiveness of PTC. The radiomics nomogram, utilizing these characteristics, displayed impressive performance with an AUC of 0.920 [95% CI, 0.889-0.950], 0.901 [95% CI, 0.839-0.963], and 0.896 [95% CI, 0.823-0.969] in the training, internal, and external validation cohort. It outperformed the clinical US, MPUS, and RS models (p < 0.05). The decision curve analysis indicated that the nomogram offered valuable clinical utility.
Conclusion:
The nomogram incorporated MPUS and radiomics have good diagnostic performance in predicting the aggressiveness of PTC which may help in the selection of the surgical modality.
