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A Review on Advances and Challenges in Core-Shell Scaffolds for Bone Tissue Engineering: Design, Fabrication, and
Bee Chin Ang1,2, Hui Yin Nam3, Muhammad Faiq Abdullah4
1Center of Advanced Materials, University Malaya, Kuala Lumpur, 50603, Malaysia.
Macromolecular Rapid Communications
|November 3, 2024
Summary
Core-shell scaffolds show promise for bone tissue engineering due to their ability to promote bone growth. Advanced fabrication and material selection are key to optimizing these scaffolds for enhanced regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bone tissue engineering aims to regenerate bone defects using scaffolds.
- Core-shell scaffolds offer unique advantages for bone regeneration.
- Osteoconductive and osteoinductive properties are crucial for scaffold efficacy.
Purpose of the Study:
- To review core-shell scaffolds in bone tissue engineering.
- To highlight key design factors and characterization methods.
- To discuss challenges and future directions in scaffold development.
Main Methods:
- Literature review of core-shell scaffolds in bone tissue engineering.
- Analysis of material selection, porosity, mechanical strength, biodegradation, and bioactivity.
- Examination of electrospun nanofibrous scaffolds and therapeutic agent delivery.
Main Results:
- Core-shell scaffolds exhibit significant osteoconductive and osteoinductive properties.
- Electrospun core-shell nanofibrous scaffolds show potential for enhanced bone regeneration.
- Various characterization techniques are essential for evaluating scaffold performance.
Conclusions:
- Core-shell scaffolds are promising for bone regeneration.
- Optimizing design factors and fabrication methods is critical.
- Further research is needed for clinical translation and commercialization.
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