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Genetic polymorphisms and bruxism: A scoping review
Júlia Meller Dias de Oliveira1, Manuella Salm Coelho1, Renata Paz Leal Pereira2
1Brazilian Centre for Evidence-Based Research (COBE), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
Sleep Medicine
|November 3, 2024
Summary
Genetic markers show potential links to bruxism susceptibility, particularly involving neurotransmitter pathways. Further research is recommended to confirm these genetic associations as risk factors for sleep (SB) and awake bruxism (AB).
Area of Science:
- Genetics
- Neuroscience
- Sleep Medicine
Background:
- Bruxism is multifactorial, influenced by behavioral, psychosocial, and physiological factors.
- Genetic predisposition is recognized as a contributing factor to bruxism.
- The specific role of genetic markers in bruxism susceptibility is not well understood.
Purpose of the Study:
- To systematically review current knowledge on genetic markers associated with bruxism.
- To investigate the susceptibility of genetic markers for sleep bruxism (SB) and awake bruxism (AB).
Main Methods:
- Searched seven electronic databases and two grey literature platforms up to January 2024.
- Included studies correlating genes/polymorphisms with bruxism types (SB/AB) in any age/sex group.
- Required studies to describe bruxism detection methods.
Main Results:
- 21 reports were included; 16 were primary research.
- Significant associations found for 15 polymorphisms across 11 genes.
- Genes in serotonergic and dopaminergic pathways showed associations with self-reported SB and AB.
Conclusions:
- Identified 30 genes and 56 polymorphisms potentially linked to SB or AB.
- Few significant positive associations were found, primarily in neurotransmitter pathways.
- Further research is needed to establish genetic markers as risk factors for bruxism.
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