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Updated: Jun 8, 2025

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Did Michelangelo paint a young adult woman with breast cancer in "The Flood" (Sistine Chapel, Rome)?
Andreas G Nerlich1, Johann C Dewaal2, Antonio Perciaccante3
1Institute of Legal Medicine, Department of Forensic Histology, Paleopathology and Mummy Research, Ludwig-Maximilians-University, Munich, Germany.
Abstract:
The Flood is the first pictorial scene that Michelangelo Buonarroti painted on the ceiling of the Sistine Chapel in the Vatican. On the right side of the fresco a woman with abnormal breast morphology is presented and the nature of her disease is considered using the Guidelines for Iconodiagnosis. A team of experts covering art history, art expertise, medicine, genetics, and pathology undertook the process and concluded that the pathology shown is probably breast cancer, most likely linked to the symbolic significance of an inevitable death as expressed in the Book of Genesis.
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