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Relationship Between Hearing Loss And Glasgow Prognostic Score In Patients With Cancer.

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Relationship Between Hearing Loss And Glasgow Prognostic Score In Patients With Cancer.

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Relationship between hearing loss and glasgow prognostic score in patients with cancer.

Shin Matsumoto¹, Yuki Hirose¹, Ryota Ishii²

¹Department of Otolaryngology, Head and Neck Surgery, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.

Auris, Nasus, Larynx

|November 3, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The Glasgow prognostic score (GPS), reflecting inflammation and malnutrition, is linked to increased hearing loss in cancer patients. This finding highlights the connection between systemic health and auditory function.

Keywords:

Glasgow prognostic score Hearing loss Pure-tone audiometry Sarcopenia Systemic inflammatory responses

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Area of Science:

Otolaryngology
Oncology
Clinical Nutrition

Background:

Oxidative stress is known to damage cochlear hair cells.
The impact of systemic inflammation and malnutrition on hearing loss in cancer patients is not well understood.
The Glasgow prognostic score (GPS) integrates systemic inflammation and nutritional status.

Purpose of the Study:

To investigate the association between the Glasgow prognostic score (GPS) and auditory threshold increases in cancer patients.
To explore the relationship between systemic inflammation, malnutrition, and hearing loss in this population.

Main Methods:

A single-center retrospective cohort study included 384 cancer patients who underwent pure-tone audiometry (PTA) between 2014 and 2023.
Multivariate analysis examined auditory thresholds in relation to covariates including GPS, age, renal function, platinum drug use, and sex.

GPS was categorized based on serum albumin and C-reactive protein levels.

Main Results:

High GPS was significantly associated with increased auditory thresholds across frequencies (500-8,000 Hz).
Older age and impaired renal function (creatinine clearance <60 mL/min) also correlated with elevated auditory thresholds.
Platinum drug use and male sex were linked to higher auditory thresholds at specific high frequencies.

Conclusions:

The Glasgow prognostic score (GPS) is an independent predictor of elevated auditory thresholds in cancer patients.
These findings suggest a link between malnutrition, chronic inflammation, and hearing loss.
The study provides insights for future research on hearing loss prevention strategies in cancer care.