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Related Experiment Videos

Luteal function after delayed ovulation.

J Balasch, M Creus, J A Vanrell

    Fertility and Sterility
    |March 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Infertility patients with long cycles often have luteal phase deficiency (LPD) despite normal progesterone. Endometrial biopsy is a better indicator of LPD than blood tests in these cases.

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    Area of Science:

    • Reproductive Endocrinology
    • Gynecology
    • Infertility Research

    Background:

    • Long follicular phases (≥20 days) in spontaneous ovulatory cycles can be associated with luteal dysfunction.
    • Evaluating luteal function is crucial for understanding infertility.
    • Previous assessments often rely on hormonal levels, potentially missing endometrial receptivity issues.

    Purpose of the Study:

    • To investigate the incidence of endometrial luteal phase deficiency (LPD) in infertile patients with long follicular phases.
    • To compare the diagnostic accuracy of endometrial biopsy versus plasma progesterone levels in detecting LPD.
    • To determine the most reliable indicator of luteal function in cycles with delayed ovulation.

    Main Methods:

    • Thirty-three infertile patients with spontaneous ovulatory cycles and long follicular phases (≥20 days) were studied.

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  • Luteal function was assessed using basal body temperature, plasma progesterone, estradiol, and prolactin.
  • Endometrial biopsy was performed to evaluate the endometrium for signs of LPD.

    • Main Results:

    • Endometrial LPD was detected in 13 out of 33 patients (39.4%).
    • In 10 of these 13 patients (77%), plasma progesterone levels were within the normal range.
    • This indicates a high incidence of endometrial LPD not identified by progesterone levels alone.

    Conclusions:

    • Endometrial LPD is common in infertile patients experiencing cycles with delayed ovulation.
    • Endometrial biopsy is a more sensitive indicator of LPD than plasma progesterone in cases related to abnormal folliculogenesis.
    • Accurate diagnosis of LPD requires considering endometrial evaluation, especially when hormonal profiles appear normal.