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Association Areas of the Cortex

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Multiscale and multimodal signatures of structure-function coupling variability across the human neocortex.

Massimiliano Facca¹, Alessandra Del Felice², Alessandra Bertoldo³

¹Padova Neuroscience Center (PNC), Padova, Italy.

|November 3, 2024

Summary

Brain structure and function coupling varies by region, impacting brain hierarchy. Microstructure and laminar specialization influence this coupling, with variable alignment enabling unique functional dynamics.

Keywords:

Connectivity Connectome Hierarchy Multimodal neuroimaging Network Structure-function

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Area of Science:

Neuroscience
Brain Imaging
Computational Biology

Background:

Brain's structural wiring and dynamic activity relationships vary regionally.
Understanding regional differences in structure-function coupling mechanisms is crucial.
The interplay between static and dynamic functional connectivity and structure needs further investigation.

Purpose of the Study:

To map structure-function coupling and its time-domain variability across the cortex.
To investigate the factors contributing to regional differences in structure-function coupling.
To explore the relationship between structure-function coupling and cortical heterogeneity.

Main Methods:

Cortical mapping of structure-function coupling and its temporal variability.
Analysis of statistical relationships with gene transcription, T1w/T2w ratio, and synaptic density.
Relating coupling properties to the brain's hierarchical organization.

Main Results:

Structure-function coupling and its variability divide the cortex into two hierarchical districts.
Macro-scale coupling is linked to micro-scale microstructure and meso-scale laminar specialization.
Lower and more variable structure-function alignment correlates with unique functional dynamics.

Conclusions:

Cortical heterogeneity shapes structure-function coupling through microstructural and laminar properties.
Regional variations in structure-function coupling are fundamental to brain organization.
Dynamic and variable structure-function coupling supports specialized functional emergence.