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BZW2 is a potential regulator of non-small cell lung cancer progression

Yan Mo1, Xueyong Feng1, Jincheng Su1

  • 1Department of Cardiovascular Thoracic Surgery, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.

Gene
|November 3, 2024
PubMed
Abstract

Insights

Basic leucine zipper and W2 domain 2 (BZW2) is elevated in non-small cell lung cancer (NSCLC), driving tumor growth and spread. Targeting BZW2 may offer a new therapeutic strategy for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genomics

Background:

  • Drug resistance is a major challenge in personalized cancer therapy.
  • Basic leucine zipper and W2 domain 2 (BZW2) is aberrantly expressed in cancer and linked to tumor progression.
  • The role of BZW2 in non-small cell lung cancer (NSCLC) warrants further investigation.

Purpose of the Study:

  • To investigate the expression and function of BZW2 in non-small cell lung cancer (NSCLC).
  • To explore BZW2 as a potential therapeutic target for NSCLC.

Main Methods:

  • Utilized The Cancer Genome Atlas (TCGA) PanCancer databases for BZW2 expression and genetic alterations.
  • Performed in vitro functional assays (CCK8, colony formation, transwell) to assess BZW2's impact on NSCLC cells.
  • Employed Gene Set Enrichment Analysis and single-cell RNA sequencing to analyze pathways and the tumor microenvironment.

Main Results:

  • BZW2 expression is significantly elevated in NSCLC and associated with tumor progression.
  • BZW2 depletion inhibited proliferation, migration, and invasion of lung squamous cell carcinoma cells.
  • BZW2 correlates with stemness-related genes and pathways like P53 signaling and RNA methylation.

Conclusions:

  • Elevated BZW2 expression promotes NSCLC proliferation, migration, and invasion.
  • BZW2 represents a potential therapeutic target for non-small cell lung cancer.
Keywords:
5MP1BZW2MigrationNon-small cell lung cancerProliferation

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