Glycans in the oral bacteria and fungi: Shaping host-microbe interactions and human health

The human oral cavity serves as the natural entry port to both the gastrointestinal and respiratory tracts, and hosts a diverse microbial community essential for maintaining health. Dysbiosis of this microbiome can lead to various diseases. Glycans, as vital carriers of biological information, are indispensable structural components of living organisms and play key roles in numerous biological processes. In the oral microbiome, glycans influence microbial binding to host receptors, promote colonization, and mediate communication among microbial communities, as well as between microbes and the host immune system. Targeting glycans may provide innovative strategies for modulating the composition of the oral microbiome, with broader implications for human health. Additionally, exogenous glycans regulate the oral microbiome by serving as carbon and energy sources for microbes, while certain specific glycans can inhibit microbial growth and activity. This review summarizes glycosylation pathways in oral bacteria and fungi, explores the regulation of host-microbiota interactions by glycans, and discusses the effects of exogenous glycans on oral microbiome. The review aims to highlight the multifaceted role of glycans in shaping the oral microbiome and its impact on the host, while also indicates potential future applications.