Related Experiment Video
Updated: Jun 8, 2025
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Out-of-hospital cardiac arrest caused by poisoning - a Swedish nationwide study over 15 years
Elin Lindqvist1, Jacob Hollenberg2, Mattias Ringh2
1Center for Resuscitation Science, Karolinska Institutet, South General Hospital, Stockholm, Sweden; Department of Anesthesiology and Intensive Care, South General Hospital, Stockholm, Sweden.
Introduction:
The epidemiology and outcomes for patients with an out-of-hospital cardiac arrest (OHCA) caused by poisoning are largely unknown and may differ from OHCA of other causes. The study's aim is to compare key characteristics and outcomes between OHCA caused by poisoning vs. other causes.
Method:
A retrospective observational study based on three Swedish national registries. All adult patients with an OHCA between January 1st 2007 and December 31st 2021 were included. The study population was divided into medical, non-medical and poisoning cause according to ICD-10-codes.
Results:
Of the 66,261 included OHCA (65.8% men, median 73 years), 89% were classified as medical and 11% non-medical. 47% of the non-medical OHCA were caused by poisoning, which represents 5.2% of all OHCA. Patients with an OHCA caused by poisoning were significantly younger (median 43 years), a larger proportion of men (67%), had the lowest frequency of witnessed event and shockable rhythm of the groups. The most common poisoning was poly-substance. The crude 30-day mortality for OHCA caused by poisoning was 83.7%, which was lower than in the medical (88%) and non-medical groups (93.8%). The adjusted 30-day mortality for OHCA caused by poisoning vs medical had an OR of 3.1 (95% CI 2.5-3.8) and vs non-medical OR 3.7 (95% CI 2.8-5.0).
Conclusion:
Patients with an OHCA caused by poisoning were younger, a larger proportion of men and had several predictors for increased mortality, yet still had a lower 30-day mortality rate when compared to other causes.
Related Concept Videos
01:14Prevention of Further Absorption of Poison
01:26Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
01:26Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
01:19Pharmacovigilance
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
01:17Antidotes
Specific antidotes operate by inhibiting the enzymes that control biochemical pathways, reducing the production of harmful metabolites.
An example of an antidote is atropine, which counteracts the detrimental effects of cholinesterase inhibitors. It achieves this by deactivating muscarinic receptors,...
01:36Types of Toxins
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...