Interaction of oat avenanthramides with starch and effects on in vitro avenanthramide bioaccessibility and starch
Chao Chen1, Yijun Yao1, Xiao Wang2
1College of Food Science and Engineering, Collaborative Innovation Center for Modern Grain Circulation and Safety, Nanjing University of Finance and Economics, Nanjing, Jiangsu 210023, China.
Abstract:
Oat avenanthramides possess multiple biologically beneficial properties. However, their interaction with starch has not been investigated. This study aims to study the interactions between avenanthramides and starches using high-performance liquid chromatography, rapid viscosity analysis, and simulated digestion. Phenolic acids were employed as a comparative group. The results demonstrated that avenanthramides exhibited higher binding rates with gelatinized starches than phenolic acids, ranging from 92.9% to 99.8%. Moreover, avenanthramides decreased the viscosity, breakdown, and setback of corn starch. Furthermore, starches slightly increased the bioaccessibility of avenanthramide 2c. Additionally, avenanthramides decreased the contents of rapidly digestible starch and slowly digesting starch in corn starch while increasing resistant starch contents. Interestingly, avenanthramides exhibited a more pronounced delaying effect on starch digestion than phenolic acids, which can be attributed to their higher binding affinity with starch. This study provides the first demonstration of the significant inhibitory effect of avenanthramides on starch digestion.
More Related Videos
Related Concept Videos
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
Carbohydrate Digestion
Introduction to Carbohydrates
Methods for Studying Drug Absorption: In vitro
The diffusion cell method uses a two-compartment cell, including a donor compartment with the drug solution, which simulates the environment where the drug is applied, and a receptor compartment with a buffer solution, which simulates the environment...
Drug Absorption: Factors Affecting GI Absorption


