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Association of Vitamin D with Haematological Inflammatory Indices in Patients with Back Pain
Yasemin Ozkan1, Mahmut Alpayci2, Veysel Delen3
1Department of Physical Medicine and Rehabilitation, Adnan Menderes University, Aydin, Turkiye.
Insights
This study found no significant link between vitamin D levels and inflammatory markers in chronic low back pain patients. Vitamin D deficiency may occur with inflammation, but not directly associated in non-inflammatory cases.
Area of Science:
- Biomedical Science
- Clinical Research
- Inflammation Studies
Background:
- Chronic low back pain (CLBP) is a prevalent condition often associated with inflammatory processes.
- Vitamin D, a crucial nutrient, has been implicated in various inflammatory conditions.
- Understanding the interplay between vitamin D and inflammation in CLBP is essential for effective management.
Purpose of the Study:
- To investigate the relationship between serum vitamin D levels and haematological inflammatory indices (HII) in patients with CLBP.
- To determine if vitamin D status correlates with specific inflammatory markers in this patient group.
Main Methods:
- A descriptive study involving 100 CLBP patients categorized into vitamin D deficiency, insufficiency, and sufficiency groups.
- Demographic data, serum parameters, and various HII were collected and compared across the groups.
- Statistical analysis was performed to assess correlations between vitamin D concentration and other measured parameters.
Main Results:
- No statistically significant differences were observed in age, gender distribution, BMI, C-reactive protein, or leucocyte counts among the vitamin D groups.
- Key haematological inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic inflammatory index (SII), showed no significant association with vitamin D levels.
- No significant correlation was found between vitamin D concentration and any of the investigated parameters (p > 0.05).
Conclusions:
- While vitamin D deficiency might coexist with inflammatory conditions, this study found no significant association between vitamin D levels and HII in patients with non-inflammatory CLBP.
- Further research is warranted to elucidate the complex role of vitamin D in chronic pain and inflammation.
Objective:
To assess the relationship between vitamin D and haematological inflammatory indices (HII) in chronic low back pain (CLBP) patients.
Study Design:
Descriptive study. Place and Duration of the Study: Harran University Hospital, Sanliurfa, Turkiye, between September 2023 and February 2024.
Methodology:
A total of 100 CLBP patients were divided into three groups according to their vitamin D levels as deficiency (<20 µg/L), insufficiency (20-30 µg/L), and sufficiency (30-80 µg/L). Demographic characteristics, serum parameters, and HII were compared among the three groups. Additionally, the association between vitamin D and other parameters were investigated.
Results:
The three groups were similar in terms of age (p = 0.640), gender distribution (p = 0.057), body mass index (BMI, p = 0.855), C-reactive protein (CRP, p = 0.965), leucocyte count (p = 0.979), neutrophil count (p = 0.525), lymphocyte count (p = 0.246), monocyte count (p = 0.485), platelet count (p = 0.878), and HII including neutrophil-to-lymphocyte ratio (NLR, p = 0.335), monocyte-to- lymphocyte ratio (MLR, p = 0.227), platelet-to-lymphocyte ratio (PLR) (p = 0.898), neutrophil-to-lymphocyte*platelet ratio (NLPR, p = 0.543), systemic inflammatory index (SII, p = 0.300), systemic inflammatory response index (SIRI, p = 0.187), and aggregate index of systemic inflammation (AISI, p = 0.219). No significant correlation was found between vitamin D concentration and other parameters (p >0.05).
Conclusion:
The coexistence of vitamin D deficiency and increased HII may accompany inflammatory conditions. However, no significant association was found between vitamin D level and HII in non-inflammatory CLBP.
Key Words:
Inflammation, Low back pain, Neutrophil, Complete blood count, Vitamin D.
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