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Targeted therapeutic strategies for the kidney
Fei Yuan1,2, Lilach O Lerman1,3
1Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Expert Opinion on Therapeutic Targets
|November 4, 2024
Summary
Novel kidney-targeted therapies show promise for treating renal disorders, offering new hope. However, challenges in clinical translation require further research and development for effective renal disorder treatments.
Area of Science:
- Nephrology
- Biomedical Engineering
- Pharmacology
Background:
- Kidney diseases present a significant global health challenge with limited effective treatments.
- Developing novel therapeutic strategies is crucial to delay or reverse kidney disease progression.
- Targeted therapies offer a promising approach to improve treatment outcomes for renal disorders.
Purpose of the Study:
- To review recent advancements in kidney-targeted therapies.
- To explore various modalities including gene, peptide, protein, cell-based, and nanoparticle delivery systems.
- To discuss the clinical applications, future prospects, and challenges of these targeted therapies for renal disorders.
Main Methods:
- Comprehensive literature review of targeted therapies for kidney diseases.
- Analysis of different delivery systems and therapeutic agents.
- Evaluation of current clinical applications and future potential.
Main Results:
- Advances in targeted therapies have shown potential to enhance treatment outcomes for renal conditions.
- Various approaches like gene therapy, peptides, proteins, cell-based therapies, and nanoparticles are being investigated.
- Localized delivery routes are also being explored for improved efficacy.
Conclusions:
- Targeted therapies hold significant promise for improving the management of kidney diseases.
- Clinical translation is hindered by the complex renal structure and a lack of specific biomarkers.
- Overcoming challenges in preclinical research and clinical application is essential for realizing the full potential of kidney-targeted therapies.
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