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Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
PICH, A protein that maintains genomic stability, can promote tumor growth
Zeyuan Li1, Wentao Zhang1, Zihan Zhang1
1The Second Clinical Medical School, Lanzhou University, Lanzhou, People's Republic of China.
Abstract:
Genomic instability is regardedas a hallmark of cancer cells. It can be presented in many ways, among which chromosome instability has received attention. Ultrafine anaphase bridges are a typeof chromatin bridges, the untimely resolution of which can also lead to chromosome instability. PICH can play a role in maintaining chromosome stability by regulating chromosome morphologyand resolving ultrafine anaphase bridges. Recently, PICH has been found to be overexpressed in various cancers. Overexpression of PICH is related to the proliferation of tumors and poor prognosis. In this article, we consider that PICH can maintain genomic stability by regulating appropriate chromosome structure, ensuring proper chromosome segregation, and facilitating replication fork reversal. We summarize how PICH regulates chromosome stability, how PICH resolves Ultrafine anaphase bridges with other proteins, and how PICH promotes tumor progression.
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